Sometimes there are topics that are triggering, even tweets from people you follow that you genuinely want to see. Heavy use of mute words significantly improves the day-to-day experience.
As of writing, it’s in Settings -> Privacy and safety -> Mute and block -> muted words.
This can be particularly useful if you enjoy following artists on Twitter, but don’t want to be bombarded by NFT spam.
Unfortunately, a hack to mute things like suggested content and topics no longer works.
See also: